Effectively Attenuated by IL-35 Memory/Effector Th2 Cell Line Can Be Induced by Dust Mite Allergen-Specific Airway Inflammation and IgE Production
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Poster 1013: IL-4R alpha antibody inhibits IgE production and airway remodeling in mouse model of house dust mite-induced eosinophilic asthma
Background Allergic asthma is associated with T helper 2 (Th2) immune response to an allergen. IL-4 and IL-13, key cytokines involved in Th2 immunity, promote eosinophilic inflammation and B cell isotype switching to IgE. House Dust Mite (HDM) allergen has been shown to induce allergic asthma in a mouse model via Th2 immune response that drives eosinophilia and influx of effector T cells into l...
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Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...
متن کاملImmune parameters in high-risk atopic individuals during early childhood.
The profile of cytokine production by peripheral blood mononuclear cells (PBMCs) from patients with bronchial asthma on stimulation with house dust mite was demonstrated to be compatible with that of helper T type 2 (Th2) cells (1). The number of Th2 cells was also shown to be increased in bronchial tissue and bronchoalveolar lavage fluid of patients with bronchial asthma. Also, the recruitment...
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BACKGROUND Although most children with asthma and rhinitis are sensitized to aeroallergens, only a minority of sensitized children are symptomatic, implying the underlying operation of efficient anti-inflammatory control mechanisms. OBJECTIVE We sought to identify endogenous control mechanisms that attenuate expression of IgE-associated responsiveness to aeroallergens in sensitized children. ...
متن کاملIL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite–induced asthma models
Previous studies have shown that IL-22, one of the Th17 cell-related cytokines, plays multiple roles in regulating allergic airway inflammation caused by antigen-specific Th2 cells; however, the underlying mechanism remains unclear. Here, we show that allergic airway inflammation and Th2 and Th17 cytokine production upon intratracheal administration of house dust mite (HDM) extract, a represent...
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